References
Click on the links below to review the literature about the ingredients in our patented formulation that has been designed to support the body against neuropathy.
(Note: a new window/tab will be open in your browser and you will be taken to a National Institutes of Health or American Diabetes Association sponsored website.)
Alpha Lipoic Acid
Effect of 4-Year Antioxidant Treatment with [alpha]-Lipoic Acid in Diabetic Polyneuropathy: The NATHAN 1 Trial ADA Scientific Session – Oral Presentation 2007
Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial. Diabetes Care. 2006 Nov;29(11):2365-70.
Predictors of alpha-lipoic acid treatment efficacy in diabetic polyneuropathy of the lower limbs. Ter Arkh. 2005;77(10):15-9.
Neuroprotection by alpha-lipoic acid in streptozotocin-induced diabetes. Biochemistry (Mosc). 2004 Sep;69(9):1001-5.
Effects of protein kinase Cbeta inhibition on neurovascular dysfunction in diabetic rats: interaction with oxidative stress and essential fatty acid dysmetabolism. Diabetes Metab Res Rev. 2002 Jul-Aug;18(4):315-23.
Effects of alpha-lipoic acid on neurovascular function in diabetic rats: interaction with essential fatty acids. Diabetologia. 1998 Apr;41(4):390-9.
Neuroprotection by the metabolic antioxidant alpha-lipoic acid. Free Radic Biol Med. 1997;22(1-2):359-78.
Gamma-Linolenic Acid (Borage Oil)
At low doses, a gamma-linolenic acid-lipoic acid conjugate is more effective than docosahexaenoic acid-enriched phospholipids in preventing neuropathy in diabetic rats. J Nutr. 2007 Feb;137(2):368-72.
Botanicals and dietary supplements in diabetic peripheral neuropathy. J Am Board Fam Pract. 2003 Jan-Feb;16(1):47-57.
Effects of protein kinase Cbeta inhibition on neurovascular dysfunction in diabetic rats: interaction with oxidative stress and essential fatty acid dysmetabolism. Diabetes Metab Res Rev. 2002 Jul-Aug;18(4):315-23.
Potential of Evening Primrose, Borage, Black Currant, and Fungal Oils in Human Health. Ann Nutr Metab. 2001;45(2):47-57.
Diabetic somatic polyneuropathy. Pathogenesis, clinical manifestations and therapeutic concepts. Fortschr Neurol Psychiatr. 2000 Jun;68(6):278-88.
Beneficial effects of gamma linolenic acid supplementation on nerve conduction velocity, Na+, K+ ATPase activity, and membrane fatty acid composition in sciatic nerve of diabetic rats. J Nutr Biochem. 1999 Jul;10(7):411-20.
Effects of alpha-lipoic acid on neurovascular function in diabetic rats: interaction with essential fatty acids. Diabetologia. 1998 Apr;41(4):390-9.
Importance of Dietary Y-Linolenic Acid in Human Health and Nutrition. The Journal of Nutrition Vol. 128 No. 9 September 1998, pp. 1411-1414
Effectiveness of natural oils as sources of gamma-linolenic acid to correct peripheral nerve conduction velocity abnormalities in diabetic rats: modulation by thromboxane A2 inhibition. Prostaglandins Leukot Essent Fatty Acids. 1996 Sep;55(3):159-65.
Benfotiamine
Diabetic neuropathy: new strategies for treatment. Diabetes Obes Metab. 2007 Jun 26.
Benfotiamine relieves inflammatory and neuropathic pain in rats. Eur J Pharmacol. 2006 Jan 13;530(1-2):48-53.
Benfotiamine in the treatment of diabetic polyneuropathy--a three-week randomized, controlled pilot study (BEDIP study). Int J Clin Pharmacol Ther. 2005 Feb;43(2):71-7.
Effectiveness of different benfotiamine dosage regimens in the treatment of painful diabetic neuropathy. Arzneimittelforschung. 1999 Mar;49(3):220-4.
Diabetic polyneuropathy treatment by milgamma-100 preparation. Zh Nevrol Psikhiatr Im S S Korsakova. 1998;98(9):30-2.
A benfotiamine-vitamin B combination in treatment of diabetic polyneuropathy. Exp Clin Endocrinol Diabetes. 1996;104(4):311-6.